Diglyme → 2-Methyl-4-phenyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

HRID 65703노트

반응식

HRID 65703 반응식
C([N:7]1[N:11]2[C:12]3[C:26]4[CH:27]=[N:28][NH:29][C:25]=4[N:24]=[CH:23][C:13]=3[C:14](=[O:22])[N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:10]2=[CH:9][CH:8]1[CH3:30])C1OC=CC=1.COCCOCCOC.[Se](=O)=O>>[CH3:30][C:8]1[CH:9]=[C:10]2[N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:14](=[O:22])[C:13]3[CH:23]=[N:24][C:25]4[NH:29][N:28]=[CH:27][C:26]=4[C:12]=3[N:11]2[N:7]=1

참가 물질

4

반응물 3

HCID 8150DiglymeHCID 24007Selenium DioxideHCID 227574691-Furfuryl-2-methyl-4-phenyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

생성물 1

HCID 227574532-Methyl-4-phenyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

실험 절차

0.01 mol. of 1-furfuryl-2-methyl-4-phenyl-4H-pyrazolo-[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one is heated in 50 ml. of diethyleneglycol dimethyl ether containing 0.01 mol. of selenium dioxide at reflux temperature with stirring for two hours. The mixture is filtered hot and evaporated to dryness. Crystalline 2-methyl-4-phenyl-4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one remains.

후처리

  1. filtrationThe mixture is filtered hot
  2. customevaporated to dryness

출처 및 근거

ORD 기록
ord-87e48bdf16e24ee0bb7856572c455513
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04128645

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