4-(2-Chloroethyl)morpholine → 2-methyl-4-(3-piperazino)propyl-4H-pyrazolo[1,5-a]-pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

HRID 65708

반응식

HRID 65708 반응식
[N:1]1([CH2:7][CH2:8][CH2:9]Cl)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.ClCCN1CCOCC1.[CH3:20][C:21]1[CH:37]=[C:24]2[NH:25][C:26](=[O:36])[C:27]3[CH:32]=[N:31][C:30]4[NH:33][N:34]=[CH:35][C:29]=4[C:28]=3[N:23]2[N:22]=1>>[CH3:20][C:21]1[CH:37]=[C:24]2[N:25]([CH2:9][CH2:8][CH2:7][N:1]3[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]3)[C:26](=[O:36])[C:27]3[CH:32]=[N:31][C:30]4[NH:33][N:34]=[CH:35][C:29]=4[C:28]=3[N:23]2[N:22]=1

참가 물질

4

반응물 3

HCID 767274-(2-Chloroethyl)morpholineHCID 5776061-(3-Chloropropyl)piperazineHCID 1357053822-methyl-4H-pyrazolo[1,5-a]pyrazolo-[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

생성물 1

HCID 227574922-methyl-4-(3-piperazino)propyl-4H-pyrazolo[1,5-a]-pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one

실험 절차

By substituting 3-piperazinopropyl chloride for the 1-chloro-2-morpholinoethane in the procedure of Example 5 and utilizing the 2-methyl-4H-pyrazolo[1,5-a]pyrazolo-[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one product of Example 8, 2-methyl-4-(3-piperazino)propyl-4H-pyrazolo[1,5-a]-pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)-one is obtained.

출처 및 근거

ORD 기록
ord-b51ac12400aa4ced99088bd62c1a6cc5
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04128645

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