Ammonia → 1-(2-carbamoylpropanoyl)-L-proline

반응식

C([O:3][C:4]([CH:6]([CH3:17])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])=O)C.[NH3:18]>>[C:4]([CH:6]([CH3:17])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=[O:3])[NH2:18]

참가 물질

반응물 2

HCID 222Ammonia

HCID 536785471-(2-ethoxycarbonylpropanoyl)-L-proline

생성물 1

HCID 542390101-(2-carbamoylpropanoyl)-L-proline

실험 절차

1-(2-Ethoxycarbonylpropanoyl)-L-proline (2 g.) is dissolved in 10% methanolic ammonia and the mixture stored at room temperature in a pressure flask. When thin layer chromatographic analysis indicates that all the starting material has been converted to the amide, the mixture is concentrated to dryness, and the residual ammonium salt is converted to the free acid with ion exchange resin (Dowex 50 hydrogen form) to obtain 1-(2-carbamoylpropanoyl)-L-proline, yield 1.1 g.

후처리

customthe mixture stored at room temperature in a pressure flask
concentrationthe mixture is concentrated to dryness

출처 및 근거

ORD 기록: ord-4b86951e21b84f2f89e44335ebe1a90c
출처 데이터셋: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04128653

반응 노트

불러오는 중…