Methanol → 2-Hydroxy-6-methylpyridine-3-carbaldehyde

HRID 657161노트

반응식

HRID 657161 반응식
[OH:1][CH2:2][C:3]1[C:4](=[O:10])[NH:5][C:6]([CH3:9])=[CH:7][CH:8]=1.C1COCC1.CO>C(Cl)Cl.O=[Mn]=O>[CH3:9][C:6]1[NH:5][C:4](=[O:10])[C:3]([CH:2]=[O:1])=[CH:8][CH:7]=1

참가 물질

6

반응물 3

HCID 887MethanolHCID 8028TetrahydrofuranHCID 202160783-(Hydroxymethyl)-6-methylpyridin-2(1H)-one

생성물 1

HCID 127224622-Hydroxy-6-methylpyridine-3-carbaldehyde수율 101%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

반응 조건

온도
57 °C

실험 절차

3-(hydroxymethyl)-6-methyl-2(1H)-pyridinone (2.0 g, 13 mmol) was dissolved in CH2Cl2(80 mL), THF (80 mL) and MeOH (5 mL), MnO2 (3.7 g, 43 mmol) was added. The reaction mixture was heated at 57° C. for 18 hours. The reaction was filtered through a pad of Celite® and concentrated to give a solid (1.8 g, 90%). LCMS (ES+) m/z 138 (MH+).

후처리

  1. filtrationThe reaction was filtered through a pad of Celite®
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-38e5c289d77b47e98b517c9b86820670
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08071592B2

반응 노트

불러오는 중…