Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cysteamine Hydrochloride → 5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cysteamine Hydrochloride | HCID 9082 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 5-((Dimethylamino)methyl)-2-furanmethanol | HCID 84906 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine | HCID 162203 | 54.2% |
반응 단계
5-(Dimethylamino)methyl-2-furanmethanol (15.5 g) was added dropwise to a stirred, ice-cold solution of cysteamine hydrochloride (11.36 g) in concentrated hydrochloric acid (40 ml). After standing at 0° for 18 hr, excess anhydrous sodium carbonate was added and the resultant solid extracted with diethyl ether. Removal of solvent followed by distillation of the residue gave 2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethanamine (11.6 g) b.p. 104-106° (0.1 mm). Picrate salt m.p. 142-144°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04128658 |
| 출처 데이터셋 | uspto-grants-1978_12 |
| ORD ID | ord-cc38c10a1e61412ba61a5b78e5106f8d |
| 출처 메모 | uspto-grants-1978_12 |