Benzoic Acid → 5-Hydroxypentyl benzoate
반응식
[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:10](O)[CH2:11][CH2:12][CH2:13][CH2:14][OH:15].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[C:1]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][OH:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of benzoic acid (1 g), 1,5-pentanediol (5 mL) and p-toluenesulfonic acid (110 mg) was heated in an oil-bath at 100° C. overnight. The reaction mixture was cooled to room temperature, poured into water (50 mL) and extracted with EtOAc (2×25 mL), washed with sodium carbonated (5%, 20 mL) followed by brine (15 mL). The organic layer was dried over anhyd. sodium sulfate, filtered and concentrated to give almost pure product (1.15 g, 67%);
후처리
- temperatureThe reaction mixture was cooled to room temperature
- extractionextracted with EtOAc (2×25 mL)
- washwashed with sodium
- customThe organic layer was dried over anhyd
- filtrationsodium sulfate, filtered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-155d34d436e840d59a60ff2dac6381b7
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08076303B2
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