2-Bromoethanol → 2-[{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]ethanol

HRID 657548노트

반응식

HRID 657548 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[C@@H:7]([CH2:13][NH:14][CH3:15])[CH2:6]2.BrC[CH2:18][OH:19].[C:20](=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[C@@H:7]([CH2:13][N:14]([CH3:20])[CH2:15][CH2:18][OH:19])[CH2:6]2

참가 물질

5

반응물 3

HCID 108982-BromoethanolHCID 11430Potassium CarbonateHCID 11499437(S)-1-(3,4-Dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)-N-methylmethanamine

생성물 1

HCID 689736902-[{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]ethanol

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

At ambient temperature, 1.04 g (5 mmol) of {[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}methylamine, 0.44 mL (6 mmol/1.2 eq.) of 2-bromoethanol and 2.07 g (15 mmol/3 eq.) of potassium carbonate are mixed into 10 mL of acetonitrile. Refluxing is carried out overnight, followed by drying. The residue is taken up in dichloromethane, washed with water and dried over magnesium sulphate to yield, after concentration, the desired product.

후처리

  1. temperatureRefluxing
  2. customby drying
  3. washwashed with water
  4. dry with materialdried over magnesium sulphate
  5. customto yield
  6. concentrationafter concentration

출처 및 근거

ORD 기록
ord-97b2131e61384ba9a12ce2533b9013f3
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076325B2

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