Ethanol → HCID 178469094, 화합물
반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.S(=O)(=O)(O)O.[CH2:16](O)[CH3:17]>>[CH2:16]([O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[N:3][CH:4]=1)[CH3:17]참가 물질
4
실험 절차
To a 100 mL three-necked flask, 0.84 g (0.006 mol) of 6-hydroxynicotinic acid, 30 mL of anhydrous ethanol were added, 3 mL of concentrated sulfuric acid was added dropwise slowly, refluxed overnight, evaporated under vacuum to remove excessive ethanol, the residue was poured into water, extracted with ethyl acetate, washed with saturated sodium hydrogen carbonate, dried with anhydrous sodium sulfate, and concentrated to obtain 0.8 g of 6-hydroxy-nicotinic acid ethyl ester. Yield: 80%.
후처리
- temperaturerefluxed overnight
- customevaporated under vacuum
- customto remove excessive ethanol
- additionthe residue was poured into water
- extractionextracted with ethyl acetate
- washwashed with saturated sodium hydrogen carbonate
- dry with materialdried with anhydrous sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-cceb857afbcd4c9baf619af6d8f86756
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08076339B2
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