Oxalyl chloride → HCID 22344169, 화합물

HRID 657606노트

반응식

HRID 657606 반응식
C(Cl)(=O)C([Cl:4])=O.[ClH:7].[C:8](O)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>ClCCl.CN(C)C=O>[ClH:4].[C:8]([Cl:7])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 57447319Benzoate hydrochloride

생성물 1

HCID 22344169HCID 22344169, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

Oxalic chloride (800 μL) is added dropwise to a solution of 4-[3-(cis and trans-3,5-dimethylpiperidino)propoxy]benzoic acid, hydrochloride (2.33 g) in dichloromethane (20 mL) containing one drop of N,N-dimethylformamide. The mixture is stirred for two hours at room temperature and concentrated under reduced pressure. Cyclohexane is added and evaporated under reduced pressure to afford 2.55 g of 4-[3-(cis and trans-3,5-dimethylpiperidino)propoxy]benzoyl chloride, hydrochloride used without further purification.

후처리

  1. concentrationconcentrated under reduced pressure
  2. additionCyclohexane is added
  3. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-a5d8d981dcbb4d4db2bba4785c0821a8
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076329B2

반응 노트

불러오는 중…