Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → HCID 23150257, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Oxalate | HCID 71081 | — |
| 반응물 | 1-(Prop-2-yn-1-yl)piperidine | HCID 336652 | — |
| 반응물 | 1-{3-[(4'-Bromobiphenyl-4-yl)oxy]propyl}piperidine | HCID 23150313 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | HCID 23150257 | HCID 23150257 | 21.4% |
반응 단계
Following the procedure described in example 43§C, but starting from 1-{3-[(4′-bromobiphenyl-4-yl)oxy]propyl}piperidine (0.75 g), 1-prop-2-yn-1-ylpiperidine (320 mg), triethylamine (20 mL), cuprous iodide (4.2 mg), triphenylphosphine (20 mg) and bis(triphenylphosphinepalladiumdichloride) affords 179 mg of 1-(3-{[4′-(3-piperidinoprop-1-yn-1-yl)biphenyl-4-yl]oxy}propyl)piperidine which oxalate melts at 195° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08076329B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-8ac4ff95480b4bbaaaf4254bd7871ada |
| 출처 메모 | uspto-grants-2011_12 |