참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Methyl quinoline-7-carboxylate | HCID 12554532 | — |
| 반응물 | (R)-3-Amino-3-(6-methylpyridin-3-yl)propan-1-ol | HCID 58103597 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 7-Quinolinemethanol | HCID 97609 | — |
반응 단계
Methyl quinoline-7-carboxylate (5 g, 0.01 mol) was dissolved in tetrahydrofuran (40 mL) at −20° C. under an atmosphere of nitrogen. 60% REDAL (60:40, Red-Al(R):toluene, 6.53 mL, 0.0201 mol) was added and allowed to stir at −20° C. for 4 hours. After warming to room temperature, the reaction was quenched slowly with water, concentrated under reduced pressure, partitioned between EtOAc and water, and filtered through Celite. The aqueous phase was extracted with EtOAc. The combined organic layers were dried with MgSO4, and concentrated under reduced pressure. The residue was purified by silica gel column to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08076345B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_12 |
|---|
| ORD ID | ord-a29d8a8117d94cc482019a592eb8f544 |
|---|
| 출처 메모 | uspto-grants-2011_12 |
|---|
