(R)-6-Benzyl-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine → (R)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

HRID 657782노트

반응식

HRID 657782 반응식
C([N:8]1[CH2:30][CH2:29][C:11]2[N:12]=[CH:13][N:14]=[C:15]([NH:16][C@@H:17]([C:19]3[CH:20]=[N:21][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:23][CH:24]=3)[CH3:18])[C:10]=2[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[F:28][C:25]([F:26])([F:27])[C:22]1[N:21]=[CH:20][C:19]([C@H:17]([NH:16][C:15]2[C:10]3[CH2:9][NH:8][CH2:30][CH2:29][C:11]=3[N:12]=[CH:13][N:14]=2)[CH3:18])=[CH:24][CH:23]=1

참가 물질

4

반응물 1

HCID 59840708(R)-6-Benzyl-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

생성물 1

HCID 59840692(R)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine수율 98.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of (R)-6-benzyl-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine (3.55 g, 8.59 mmol), 10% palladium on charcoal (740 mg), and methanol (60 mL) were stirred under hydrogen (1 atm) for 15 h. The catalyst was filtered off through Celite and the filter cake was washed with MeOH (3×30 mL). The filtrate was concentrated to obtain an off-white foam (2.74 g, 98% yield).

후처리

  1. filtrationThe catalyst was filtered off through Celite
  2. washthe filter cake was washed with MeOH (3×30 mL)
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-76b044b0dd6b41dbbafce2f1e6f88750
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076345B2

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