Water → HCID 25060062, 화합물

HRID 657808노트

반응식

HRID 657808 반응식
[Si]([O:8][CH2:9][C@@H:10]([NH:19][C:20]1[C:21]2[CH2:29][N:28]([C:30]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:31]=3[C:32]#[N:33])[CH2:27][CH2:26][C:22]=2[N:23]=[CH:24][N:25]=1)[C:11]1[CH:12]=[N:13][C:14]([O:17][CH3:18])=[N:15][CH:16]=1)(C(C)(C)C)(C)C.CCCC[N+](CCCC)(CCCC)CCCC.[F-].O.CCOC(C)=O>C1COCC1>[OH:8][CH2:9][C@@H:10]([NH:19][C:20]1[C:21]2[CH2:29][N:28]([C:30]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][C:31]=3[C:32]#[N:33])[CH2:27][CH2:26][C:22]=2[N:23]=[CH:24][N:25]=1)[C:11]1[CH:16]=[N:15][C:14]([O:17][CH3:18])=[N:13][CH:12]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 2724141Tetrabutylammonium FluorideHCID 69177701HCID 69177701, 화합물

생성물 1

HCID 25060062HCID 25060062, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of (S)-2-(4-(2-(tert-butyldimethylsilyloxy)-1-(methoxypyrimidin5-yl)ethylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-5-methylbenzonitrile (740 mg, 1.39 mmol) in THF (10 mL) was added 1M TBAF in THF (5 mL). The reaction mixture was stirred at room temperature for 10 minutes, and then treated with water and EtOAc. The organic layer was washed with aq. NaHCO3 and brine, dried (MgSO4), and concentrated. The residue was purified by semi-preparative HPLC to yield a white solid.

후처리

  1. washThe organic layer was washed with aq. NaHCO3 and brine
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated
  4. customThe residue was purified by semi-preparative HPLC
  5. customto yield a white solid

출처 및 근거

ORD 기록
ord-36f6e397d01a4b77bab4726712777fc3
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076345B2

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