Sulfuric Acid → 4-(Butylamino)-1-ethyl-5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-11(1H)-one

HRID 65781

반응식

HRID 65781 반응식
[CH2:1]([NH:5][C:6]1[C:11]2[CH:12]=[N:13][N:14]([CH2:15][CH3:16])[C:10]=2[N:9]=[C:8]2[C:17](=NCCCC)[C:18]3[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=3[CH2:20][CH2:21][C:7]=12)[CH2:2][CH2:3][CH3:4].S(=O)(=O)(O)[OH:32]>C(OCC)(=O)C.CCOCC>[CH2:1]([NH:5][C:6]1[C:11]2[CH:12]=[N:13][N:14]([CH2:15][CH3:16])[C:10]=2[N:9]=[C:8]2[C:17](=[O:32])[C:18]3[CH:25]=[CH:24][CH:23]=[CH:22][C:19]=3[CH2:20][CH2:21][C:7]=12)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 22757739N-Butyl-11-(butylimino)-1-ethyl-1,5,6,11-tetrahydrobenzo-[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-4-amine

생성물 1

HCID 227577664-(Butylamino)-1-ethyl-5,6-dihydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-11(1H)-one

시약·촉매·용매 1

HCID 21584169Diethylether ethylacetate용매

실험 절차

7.2 g. of N-butyl-11-(butylimino)-1-ethyl-1,5,6,11-tetrahydrobenzo[5,6]cyclohepta[1,2-b]pyrazolo[4,3-e]pyridin-4-amine (0.018 mol.) and 100 ml. of aqueous sulfuric acid (30%) are reacted according to the procedure of Example 6, yield: 4.7 g. (75%); m.p. 181°-183° (ethyl acetate/ether).

출처 및 근거

ORD 기록
ord-1b0a258bfe104ae1a025a9460502811f
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04128717

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