Sodium ethoxide → 6-Ethoxy-8-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine

HRID 657858

반응식

HRID 657858 반응식
Br.Cl[C:3]1[CH:4]=[C:5]([CH3:13])[C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1.[O-:14][CH2:15][CH3:16].[Na+]>C(O)C>[CH2:15]([O:14][C:3]1[CH:4]=[C:5]([CH3:13])[C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1)[CH3:16]

참가 물질

4

반응물 2

HCID 2723922Sodium ethoxideHCID 866507966-Chloro-8-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide

생성물 1

HCID 580459206-Ethoxy-8-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine수율 96.4%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

6-Chloro-8-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.002; 2.5 g) were dissolved in ethanol (50 ml), admixed under argon with sodium ethoxide (3.86 g) and stirred at 60° C. for 1 h. Then the mixture was dried and the residue was purified using a 40 g silica gel cartridge (0-20% dichloromethane-ethanol gradient in 40 min). The clean product fractions were combined and dried. 1.76 g of the title compound were obtained.

후처리

  1. customThen the mixture was dried
  2. customthe residue was purified
  3. customa 40 g silica gel cartridge (0-20% dichloromethane-ethanol gradient in 40 min)
  4. customdried

출처 및 근거

ORD 기록
ord-cc3a1c9771c64979ba276fe96faaabe4
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076336B2

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