Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Propanol → 7,8-Dimethyl-6-propoxy-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Propanol | HCID 1031 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 6-Chloro-7,8-dimethyl-[1,2,4]triazolo[4,3-B]pyridazin-3-amine | HCID 58045804 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7,8-Dimethyl-6-propoxy-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine | HCID 58045953 | — |
반응 단계
1-Propanol (28 ml) was deprotonated analogously to W1.056 with sodium hydride (1.3 g) and reacted with 6-chloro-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W2.006a, 1 g), dissolved in 1-propanol (10 ml) and DMF (10 ml), and worked up. 647 mg of the title compound were isolated in sufficient purity.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08076336B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-38c169b71e6447ef950376f75ace503a |
| 출처 메모 | uspto-grants-2011_12 |