1,1-Dimethylhydrazine → alpha-Dimethylhydrazinocarbonylamino-2-thiopheneacetic acid

HRID 65796

반응식

HRID 65796 반응식
[N:1]([CH:4]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]([O:7]CC)=[O:6])=[C:2]=[O:3].[CH3:15][N:16]([CH3:18])[NH2:17].C(Cl)Cl>C(O)(=O)C>[CH3:15][N:16]([CH3:18])[NH:17][C:2]([NH:1][CH:4]([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]([OH:7])=[O:6])=[O:3]

참가 물질

5

반응물 3

HCID 59761,1-DimethylhydrazineHCID 6344DichloromethaneHCID 54068691alpha-Isocyanato-2-thiopheneacetic acid, ethyl ester

생성물 1

HCID 54530029alpha-Dimethylhydrazinocarbonylamino-2-thiopheneacetic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 4.2 g. (0.02 mole) of DL-α-isocyanato-2-thiopheneacetic acid, ethyl ester and 1.2 g. (0.02 mole) of N,N-dimethylhydrazine in 80 ml. of methylene chloride is stirred overnight. The solution is concentrated and to the syrupy residue are added 10 ml. of 2N sodium hydroxide solution. After stirring for 30 minutes, a clear yellow solution results. By the addition of acetic acid, 3.9 g. of α-dimethylhydrazinocarbonylamino-2-thiopheneacetic acid are obtained, m.p. 208°-210°.

후처리

  1. concentrationThe solution is concentrated and to the syrupy residue
  2. additionare added 10 ml
  3. customa clear yellow solution results

출처 및 근거

ORD 기록
ord-208d1fa98d07437e8ee5455d106b3405
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04128724

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