Carbonochloridothioic acid, S-phenyl ester → (1-cyano1-methylethyl)carbamothioic acid, S-phenyl ester
반응식
[NH2:1][C:2]([CH3:6])([CH3:5])[C:3]#[N:4].[C:7]1([S:13][C:14](Cl)=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>O1CCOCC1>[C:3]([C:2]([NH:1][C:14](=[O:15])[S:13][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([CH3:6])[CH3:5])#[N:4]참가 물질
4
실험 절차
3.4 g. (0.04 mole) of 2-amino-2-methylpropanonitrile are dissolved in 10 ml. of dioxane and a solution of 3.2 ml. (0.2 mole) of (phenylthio)carbonyl chloride in 10 ml. of dioxane is added. After stirring for one hour at room temperature, the reaction mixture is filtered, the filtrate is concentrated, and the solid residue is recrystallized from a small amount of toluene to yield 2.7 g of (1-cyano1-methylethyl)carbamothioic acid, S-phenyl ester; m.p. 152°-155°.
후처리
- filtrationthe reaction mixture is filtered
- concentrationthe filtrate is concentrated
- customthe solid residue is recrystallized from a small amount of toluene
출처 및 근거
- ORD 기록
- ord-f4ecdca4ae7c4dfea97c7b618470ddd7
- 출처 데이터셋
- uspto-grants-1978_12
- 특허 번호
- US04128723
반응 노트
불러오는 중…