Ethyl ketone → 2-Cyclohexen-1-one, 2,5,6-trimethyl-

HRID 65803노트

반응식

HRID 65803 반응식
CO[CH:3]([CH3:7])[CH2:4][CH:5]=[O:6].[CH2:8]([C:10]([CH2:12]C)=O)[CH3:9].[CH3:14][O-].[Na+]>CO>[CH3:14][C:4]1[C:5](=[O:6])[CH:8]([CH3:9])[CH:10]([CH3:12])[CH2:7][CH:3]=1

참가 물질

5

반응물 3

HCID 7288Ethyl ketoneHCID 980403-MethoxybutyraldehydeHCID 10942334Sodium Methoxide

생성물 1

HCID 892642-Cyclohexen-1-one, 2,5,6-trimethyl-수율 56%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

102 g of β-methoxybutyraldehyde is dripped in the course of one hour into a mixture of 500 g of diethyl ketone and 10 g of a 30% solution of sodium methylate in methanol which is boiling under reflux. The whole is then heated for another hour under reflux. The reaction mixture is processed as described in Example 2. 77 g of 2,5,6-trimethyl-2-cyclohexen-1-one is obtained, i.e. a 56% yield with reference to β-methoxybutyraldehyde.

후처리

  1. temperatureunder reflux
  2. temperatureThe whole is then heated for another hour
  3. temperatureunder reflux

출처 및 근거

ORD 기록
ord-9c14c87cead5429790577056f90c7ce5
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04128728

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