HCID 12979375, 화합물 → 3,7-dimethyl-1H-indole-2-carboxylic acid

반응식

C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[CH3:15])=[CH:12][CH:11]=[CH:10][C:9]=2[CH3:16])=[O:5])C.ClC1C=C2C(=C(CC#N)C=1)NC(C(O)=O)=C2>>[CH3:15][C:14]1[C:13]2[C:8](=[C:9]([CH3:16])[CH:10]=[CH:11][CH:12]=2)[NH:7][C:6]=1[C:4]([OH:5])=[O:3]

참가 물질

반응물 2

HCID 12979375HCID 12979375, 화합물

HCID 59740493HCID 59740493, 화합물2회

생성물 1

HCID 223381583,7-dimethyl-1H-indole-2-carboxylic acid

실험 절차

The title compound is prepared by saponification of 3,7-dimethyl-1H-indole-2-carboxylic acid ethyl ester (prepared by Fischer indole synthesis as described in Tetrahedron Lett. 2003, 44, 5665) using the procedure described above for the synthesis of 5-chloro-7-cyanomethyl-1H-indole-2-carboxylic acid (acid 1, step g)).

출처 및 근거

ORD 기록: ord-42e79b57106e43e3be1f75e97538346c
출처 데이터셋: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08076360B2

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