Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chloro-5-fluoro-1,2-phenylenediamine → 5-chloro-6-fluoro-2-methyl-1H-benzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chloro-5-fluoro-1,2-phenylenediamine | HCID 735773 | — |
| 반응물 | Ethyl ortho-acetate | HCID 86598186 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-chloro-6-fluoro-2-methyl-1H-benzimidazole | HCID 55281565 | 39% |
반응 단계
A 4.96 g portion of ethyl orthoacetate dissolved in 10 ml of ethanol was added to 50 ml of ethanol solution containing 4.68 g of 4-chloro-5-fluorobenzene-1,2-diamine and heated under reflux for 4 hours. After concentration of the reaction liquid, the thus formed residue was purified by a silica gel column chromatography to obtain 2.10 g (39%) of 5-chloro-6-fluoro-2-methyl-1H-benzimidazole from a chloroform-methanol (10:1) eluate. ES+: 185
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08076367B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-3808743c057d473893bf85eb35750524 |
| 출처 메모 | uspto-grants-2011_12 |