Acetone → HCID 178484388, 화합물
반응식
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].CC(C)=O.O.[C:15]([OH:23])(=[O:22])[CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>CC(C)=O.O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:15]([O-:23])(=[O:22])[CH2:16][CH2:17][CH2:18][C:19]([O-:21])=[O:20]참가 물질
6
반응 조건
- 온도
- 10 °C
실험 절차
9.75 g (2.5 molar equivalents) of the metformin free-base was stirred in a mixed solution of 112.5 ml of acetone and 5 ml of water at 40° C., and a solution of 3.98 g (1 molar equivalent) of glutaric acid in acetone-water was added dropwise thereto and stirred at 10° C. The produced crystal was filtered and dried in hot air, thus obtaining 11.24 g (yield: 95.3%) of metformin glutarate.
후처리
- filtrationThe produced crystal was filtered
- customdried in hot air
출처 및 근거
- ORD 기록
- ord-b1476a9df4084ce29a100deb4b1d44bd
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08076377B2
반응 노트
불러오는 중…