Methyl 3-aminothieno(2,3-b)pyridine-2-carboxylate → Methyl thieno[2,3-b]pyridine-2-carboxylate
반응식
N[C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[S:4][C:3]=1[C:11]([O:13][CH3:14])=[O:12].N([O-])=O.[Na+]>>[S:4]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:10]2[CH:2]=[C:3]1[C:11]([O:13][CH3:14])=[O:12]참가 물질
3
실험 절차
The synthesis is carried out according to the general procedure; for work-up, the resulting precipitate is filtered off with suction and washed twice with water and three times with ethyl acetate. The organic phase of the resulting filtrate is separated off, dried and concentrated. Using 0.22 g (1.07 mmol) of methyl 3-aminothieno[2,3-b]pyridine-2-carboxylate and 0.24 g (3.41 mmol) of sodium nitrite, 84 mg (41% of theory) of the desired product are obtained.
후처리
- filtrationfor work-up, the resulting precipitate is filtered off with suction
- washwashed twice with water and three times with ethyl acetate
- customThe organic phase of the resulting filtrate is separated off
- customdried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-28e46e2cb2014e02ab6e4d0a5b122ce3
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08076355B2
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