N,O-Dimethylhydroxylamine → Urea, N-methoxy-N-methyl-N'-(4-(2-(4-methylphenyl)ethoxy)phenyl)-

HRID 65819

반응식

HRID 65819 반응식
[CH3:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]=[C:16]=[O:17])=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[CH3:20][NH:21][O:22][CH3:23]>C1C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16](=[O:17])[N:21]([O:22][CH3:23])[CH3:20])=[CH:11][CH:10]=2)=[CH:18][CH:19]=1

참가 물질

4

반응물 2

HCID 14232N,O-DimethylhydroxylamineHCID 130176584-(4-Methylphenethyloxy)phenyl isocyanate

생성물 1

HCID 93385Urea, N-methoxy-N-methyl-N'-(4-(2-(4-methylphenyl)ethoxy)phenyl)-수율 108.4%

시약·촉매·용매 1

HCID 241Benzene용매2회

실험 절차

Into a solution of 5.5 g of 4-(4-methylphenethyloxy)phenyl isocyanate in 100 ml of benzene, a solution of 2 g of N,O-dimethylhydroxylamine in 50 ml of benzene is added dropwise at 20° to 30° C. After the addition is finished, the reaction mixture is continuously stirred at the same temperature for an additional 30 minutes. Thereafter, the solvent is removed under reduced pressure, and the residue is recrystallized from ethanol to obtain 7.4 g of N'-[4-(4-methylphenethyloxy)phenyl]-N-methoxy-N-methylurea as white needles, M.P. 82°-83° C.

후처리

  1. additionAfter the addition
  2. customThereafter, the solvent is removed under reduced pressure
  3. customthe residue is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-a066c1df694a417684942b3232fa807c
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129436

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