Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → N'-[4-(4-tert-butylphenethyloxy)phenyl]-N-methoxy-N-methylurea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | Einecs 211-027-4 | HCID 69401 | — |
| 반응물 | N-methoxy-N-methylcarbamoyl chloride | HCID 2734926 | — |
| 반응물 | 4-(4-Tert-butylphenethyloxy)aniline | HCID 22756001 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N'-[4-(4-tert-butylphenethyloxy)phenyl]-N-methoxy-N-methylurea | HCID 22756005 | 26.1% |
반응 단계
A mixture of 26.9 g of 4-(4-tert-butylphenethyloxy)aniline, 13 g of N-methoxy-N-methylcarbamyl chloride, 10 ml of pyridine and 300 ml of toluene is heated under reflux for 7 hours. Thereafter, water is added to dissolve pyridinium chloride, and the separated toluene layer is washed with dilute hydrochloric acid, thoroughly washed with water and dried over anhydrous sodium sulfate. The solvent is then removed under reduced pressure, and the crude crystals obtained are repeatedly recrystallized from ethanol to obtain 9.3 g of N'-[4-(4-tert-butylphenethyloxy)phenyl]-N-methoxy-N-methylurea as white needles, M.P. 14°-15° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04129436 |
| 출처 데이터셋 | uspto-grants-1978_12 |
| ORD ID | ord-af08b02af2aa4bca8204bcf5fa2b9ff0 |
| 출처 메모 | uspto-grants-1978_12 |