(S)-(5-Isobutyl-indan-2-yl)-carbamic acid benzyl ester → (S)-5-Isobutyl-indan-2-ylamine
반응식
C(OC(=O)[NH:10][C@@H:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([CH2:20][CH:21]([CH3:23])[CH3:22])[CH:17]=2)[CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[CH2:20]([C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[CH2:12][C@H:11]([NH2:10])[CH2:19]2)[CH:21]([CH3:23])[CH3:22]참가 물질
4
실험 절차
(S)-(5-Isobutyl-indan-2-yl)-carbamic acid benzyl ester ( ) is dissolved in methanol (100 ml), 10% Pd—C (200 mg) is added and the flask is purged with H2(g) (0.35 bar). The reaction mixture is stirred for 18 hours, the catalyst is filtered off. The solvent is removed in vacuo to give title compound. 1H nmr (CDCl3, 400 MHz); 7.10 (d, 1H), 7.00 (s, 1H), 6.90 (d, 1H), 3.85 (m, 1H), 3.15 (dd, 2H), 2.65 (dt, 2H), 2.45 (d, 2H), 1.80 (br m, 3H), 0.90 (d, 6H).
후처리
- customthe flask is purged with H2(g) (0.35 bar)
- filtrationthe catalyst is filtered off
- customThe solvent is removed in vacuo
출처 및 근거
- ORD 기록
- ord-708b1d64f8ef48c5bba09818ad6390db
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08076489B2
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