Nitroxoline → 5-Amino-8-hydroxyquinoline

반응식

[OH:1][C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-])=O)=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.NC1C=CC(O)=CC=1F>>[NH2:12][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[C:11]2[C:6]=1[CH:7]=[CH:8][CH:9]=[N:10]2

참가 물질

반응물 2

HCID 19910Nitroxoline

HCID 27359194-Amino-3-fluorophenol

생성물 1

HCID 4160025-Amino-8-hydroxyquinoline수율 57%

실험 절차

This compound was prepared from 8-hydroxy-5-nitroquinoline (5.0 g, 26.3 mmol) in the manner described for 4-amino-3-fluorophenol, affording 2.4 g (51.3%) of 5-amino-8-hydroxyquinoline. TLC (5% MeOH/DCM), Rf=0.52.

출처 및 근거

ORD 기록: ord-1507a0dd847d4b5abdeed4758b6e6078
출처 데이터셋: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08076488B2

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