Dichloromethane → Isophthaloyl chloride

HRID 65888

반응식

HRID 65888 반응식
[C:1]([OH:12])(=[O:11])[C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=O)[CH:3]=1.[Cl:13][CH2:14]Cl.[C:16]([Cl:19])(Cl)=[O:17]>N1C=CC=CC=1>[C:5]([O:17][CH3:16])(=[O:7])[C:4]1[CH:8]=[CH:9][CH:10]=[C:2]([C:1]([O:12][CH3:14])=[O:11])[CH:3]=1.[C:16]([Cl:19])(=[O:17])[C:4]1[CH:8]=[CH:9][CH:10]=[C:2]([C:1]([Cl:13])=[O:12])[CH:3]=1

참가 물질

6

반응물 3

HCID 6344Dichloromethane2회HCID 6371PhosgeneHCID 8496Isophthalic Acid

생성물 2

HCID 7451Isophthaloyl chloride수율 100%HCID 15088Dimethyl isophthalate수율 100%

시약·촉매·용매 1

HCID 1049Pyridine용매2회

실험 절차

Following the general procedure of Example 9, a slurry of 7.46 parts isophthalic acid in 80 parts dry dichloromethane was added to a mixture of 7.91 parts pyridine and 9.77 parts phosgene in 210 parts dry dichloromethane at 25° to 30° C. The ratio of equivalents of pyridine base/COOH acid group was 1.10. After carrying out the reaction and esterifying the resulting diacid chloride by the procedure described in Example 1 there was obtained a 100% yield of dimethyl isophthalate corresponding to a 100% yield of isophthaloyl chloride formed initially in the reaction.

후처리

  1. customthe reaction

출처 및 근거

ORD 기록
ord-e44ba75980794305bf5840b64cd568a9
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129594

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