Phthalimide → 2-(2-(3-Bromobenzyloxy)ethyl)isoindoline-1,3-dione

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[CH2:5][O:6][CH2:7][CH2:8]O.[C:13]1(=[O:23])[NH:17][C:16](=[O:18])[C:15]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:14]12>>[Br:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[CH2:5][O:6][CH2:7][CH2:8][N:17]1[C:13](=[O:23])[C:14]2[C:15](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:16]1=[O:18]

참가 물질

반응물 2

HCID 6809Phthalimide

HCID 579568182-(3-Bromobenzyloxy)ethanol

생성물 1

HCID 667438742-(2-(3-Bromobenzyloxy)ethyl)isoindoline-1,3-dione

실험 절차

Mitsunobu reaction of 2-(3-bromobenzyloxy)ethanol and phthalimide following the method used in Example 134 gives 2-(2-(3-bromobenzyloxy)ethyl)isoindoline-1,3-dione.

출처 및 근거

ORD 기록: ord-e806a49d41c2408196b3c164df5e6a64
출처 데이터셋: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08076516B2

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