Methanol → HCID 23249620, 화합물

HRID 658961노트

반응식

HRID 658961 반응식
[O:1]([CH2:9][CH2:10][CH2:11][CH2:12]/[CH:13]=[C:14](\[CH3:20])/[C:15](OCC)=[O:16])[Si:2]([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3].[H-].C([Al+]CC(C)C)C(C)C.CCCCCC.CO.O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>C(Cl)Cl>[O:1]([CH2:9][CH2:10][CH2:11][CH2:12]/[CH:13]=[C:14](\[CH3:20])/[CH2:15][OH:16])[Si:2]([C:5]([CH3:7])([CH3:8])[CH3:6])([CH3:4])[CH3:3]

참가 물질

6

반응물 4

HCID 887MethanolHCID 62649Sodium sulfate decahydrateHCID 11055704(E)-ethyl 7-(tert-butyldimethylsiloxy)-2-methyl-2-heptenateHCID 21273587HCID 21273587, 화합물

생성물 1

HCID 23249620HCID 23249620, 화합물수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a methylene chloride solution (200 ml) of Ester 4 (15.84 g; 0.0528 mol), a 0.95 M diisobutylaluminiumhydride-hexane solution (139 ml; 0.132 mol) is added at 0° C. and the whole is stirred for 1 hour. After stirring, methanol (7 ml; 0.160 mol) and sodium sulfate decahydrate (68.0 g; 0.211 mol) are added thereto and the whole is stirred at room temperature for 30 min. Sodiumsulfatedecahydrate is filtered using Chloroform (21), and the solvent is distilled off under reduced pressure to produce Alcohol 5 (13.60 g; 0.0528 mol) of 100% in yield.

후처리

  1. stirringAfter stirring
  2. stirringthe whole is stirred at room temperature for 30 min
  3. filtrationSodiumsulfatedecahydrate is filtered
  4. distillationthe solvent is distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-40b47e8a91e14055884f7acca915c8ef
출처 데이터셋
uspto-grants-2011_12
특허 번호
USRE043038E1

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