Sodium ethoxide → 4-Oxo-pyrrolidine-1,3-dicarboxylic acid diethyl ester

HRID 659045노트

반응식

HRID 659045 반응식
[CH2:1]([O:3][C:4]([N:6]([CH2:14][C:15]([O:17]CC)=O)[CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:5])[CH3:2].CC[O-].[Na+]>CCO>[O:17]=[C:15]1[CH2:14][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7][CH:8]1[C:9]([O:11][CH2:12][CH3:13])=[O:10]

참가 물질

4

반응물 2

HCID 2723922Sodium ethoxideHCID 4381617ethyl 3-[ethoxycarbonyl-(2-ethoxy-2-oxoethyl)amino]propanoate

생성물 1

HCID 2763144-Oxo-pyrrolidine-1,3-dicarboxylic acid diethyl ester

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

Intermediate (e) (18.0 g, 65.2 mmol) was added to an ice bath cooled solution of NaOEt (32.6 mL) (21% by weight in EtOH) in absolute EtOH (41.7 mL) under a nitrogen atmosphere. The ice bath was removed and the mixture was heated at 80° C. for about 12 h until the condensation was complete as observed by TLC. The mixture was poured onto ice/water and extracted into EtOAc. The solvent was dried with Na2SO4, filtered, and evaporated to afford crude intermediate (f) as an off white solid (14.05 g) which was carried on without purification.

후처리

  1. customThe ice bath was removed
  2. additionThe mixture was poured onto ice/water
  3. extractionextracted into EtOAc
  4. dry with materialThe solvent was dried with Na2SO4
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-cdf601ddefbc45f5a832363300a87067
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080556B2

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