Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 3-{3-[(5-Phenoxy-furan-2-carbonyl)-amino]-phenyl}-acrylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| 반응물 | 5-Phenoxyfuran-2-carboxylic acid | HCID 2812790 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-{3-[(5-Phenoxy-furan-2-carbonyl)-amino]-phenyl}-acrylic acid | HCID 68413660 | — |
반응 단계
5-phenoxy-2-furoic acid (3) (213 mg, 1.05 mmol) was coupled to aniline (2) (200 mg, 1.05 mmol) using Method B, except that DIPEA (270 mg, 2.09 mmol) and DMF (2 mL) were used to give the title compound. Yield: 178 mg, 96%; LC/MS tr 1.65 min; HPLC Purity: 95%; MS (ES+) m/z 378 (M+H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08080567B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-b572637309d44c8aa5c4bf03177b49eb |
| 출처 메모 | uspto-grants-2011_12 |