Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 3-{3-[(5-Benzoyl-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| 반응물 | 5-Benzoylfuran-2-carboxylic acid | HCID 2877255 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-{3-[(5-Benzoyl-furan-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 68412610 | — |
반응 단계
Acid (9) (48 mg, 0.22 mmol) was coupled to aniline (2) (43 mg, 0.22 mmol) using Method B, except that DIPEA (57 mg, 0.44 mmol) and DMF (0.5 mL) were used. The crude product was purified by preparative HPLC to give the title compound. Yield: 28 mg; LC-MS tr 41.54 min; MS (ES+) m/z 389 (M+H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08080567B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-1a215cd9103e447a89e05584481b6c9e |
| 출처 메모 | uspto-grants-2011_12 |