Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Aminocinnamic acid ethyl ester → 3-{3-[(Dibenzofuran-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Aminocinnamic acid ethyl ester | HCID 97825 | — |
| 반응물 | 8-Oxatricyclo(7.4.0.0,2,7)trideca-1(9),2(7),3,5,10,12-hexaene-4-carboxylic acid | HCID 417404 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-{3-[(Dibenzofuran-2-carbonyl)-amino]-phenyl}-acrylic acid ethyl ester | HCID 68413672 | — |
반응 단계
Acid (18) (50 mg, 0.24 mmol) was coupled to aniline (2) (54 mg, 0.28 mmol) using Method D, except that DMF (1 mL) was used. The product was further purified by trituration in DCM/heptane to give the title compound. Yield: 46 mg, 51%; LC-MS tr 1.70 min; HPLC Purity: 97-100%; MS (ES+) m/z 386 (M+H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08080567B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-b2c3063bdbde41079b807c139c24d1af |
| 출처 메모 | uspto-grants-2011_12 |