참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | Bromobenzene | HCID 7961 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Furan-2-boronic acid | HCID 2734357 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-Phenylfuran | HCID 519363 | — |
반응 단계
Furan-2-boronic acid (22) (3.6 g, 32.14 mmol) was coupled to bromobenzene (21) (4.2 g, 26.79 mmol) using Method E, except that Cs2CO3 (17.47 g, 53.58 mmol), Pd(PPha)4 (6.20 g, 0.54 mmol), toluene (25 mL) and EtOH (25 mL) were used and the reaction heated in a CEM Discover microwave at 140° C. (200 W, 200 psi). The crude product was purified by dry-flash chromatography eluting with EtOAc in heptane to yield the title compound. Yield: 2.94 g, 62%; LC tr 1.50 min; HPLC Purity: 84%
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08080567B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_12 |
|---|
| ORD ID | ord-c5527ea8e52d4a509b9aae5f8e6b5360 |
|---|
| 출처 메모 | uspto-grants-2011_12 |
|---|
