Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 3-[3-(5-Phenyl-benzoxazol-2-yl)-phenyl]-acrylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 3-[3-(5-Phenyl-benzoxazol-2-yl)-phenyl]-acrylic acid methyl ester | HCID 68416975 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-[3-(5-Phenyl-benzoxazol-2-yl)-phenyl]-acrylic acid | HCID 68414204 | — |
반응 단계
The ester (33) (41 mg, 0.12 mmol) was hydrolysed using Method C, except that MeOH (3 mL), THF (3 mL) and 1M NaOH (5 mL) were used, and the reaction was stirred for 2 hours. Yield: 21 mg, 53%; LC-MS tr 1.74 min; HPLC Purity: 96%; MS (ES+) m/z 342 (M+H); 1H NMR (400 MHz; DMSO): δ 6.7 (d, 1H), 7.4 (t, 1H), 7.45-7.55 (t, 2H), 7.70-7.80 (m, 5H), 7.9 (d, 1H), 8.05 (d, 1H), 8.10 (s, 1H), 8.30 (d, 1H), 8.50 (s, 1H), 12.55 (br. s, 1H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08080567B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-1cbcba417ca24b8fb7e52db701996fee |
| 출처 메모 | uspto-grants-2011_12 |