1,2-Diaminocyclohexane, cis- → cis-N-(2-Amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

반응식

[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@@H:3]1[NH2:8].[F:9][C:10]([F:27])([F:26])[C:11]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[C:16]([O:24][CH3:25])[C:12]=1[C:13](O)=[O:14]>>[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:13](=[O:14])[C:12]1[C:11]([C:10]([F:26])([F:27])[F:9])=[CH:19][C:18]([C:20]([F:21])([F:22])[F:23])=[CH:17][C:16]=1[O:24][CH3:25]

참가 물질

반응물 2

HCID 3429171,2-Diaminocyclohexane, cis-

HCID 27412872-Methoxy-4,6-bis(trifluoromethyl)benzoic acid

생성물 1

HCID 58062915cis-N-(2-Amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

실험 절차

The title compound, yellow foam, MS: m/e=385.1 [(M+H)+], was prepared in accordance with the general method of intermediate G from cis-1,2-diaminocyclohexane and 2,4-bis(trifluoromethyl)-6-methoxybenzoic acid.

출처 및 근거

ORD 기록: ord-60523d04e48f47dcb09e94332e175576
출처 데이터셋: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08080541B2

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