돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 659235생성일: 2026년 10월 26일

1,4-Dibromo-2-butanol → N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-4,6-bis-trifluoromethyl-benzamide

https://huagongshe.com/reaction/659235

반응식

참여 물질

역할이름HCID투입량
반응물1,4-Dibromo-2-butanolHCID 29570—
반응물cis-N-(2-Amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamideHCID 58062915—
생성물N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-4,6-bis-trifluoromethyl-benzamideHCID 76682981—

반응 단계

The title compounds, both light yellow solids, MS: m/e=455.3 [(M+H)+], were prepared in accordance with the general method of example 10 from cis-N-(2-amino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide (intermediate H) and 1,4-dibromo-2-butanol. The 2 diastereomers could be separated by column chromatography however the relative configuration was not assigned.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08080541B2
출처 데이터셋uspto-grants-2011_12
ORD IDord-14d90036ec694c1f9b1c206b9f242724
출처 메모uspto-grants-2011_12