2-Ethyl-4-(trifluoromethyl)benzoic acid → cis-2-Ethyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-4-trifluoromethyl-benzamide

HRID 659238

반응식

HRID 659238 반응식
Cl.Cl.[N:3]1([C@H:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:14])[CH2:7][CH2:6][CH2:5][CH2:4]1.[CH2:15]([C:17]1[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:23]=[CH:22][C:18]=1[C:19](O)=[O:20])[CH3:16]>>[CH2:15]([C:17]1[CH:25]=[C:24]([C:26]([F:27])([F:28])[F:29])[CH:23]=[CH:22][C:18]=1[C:19]([NH:14][C@@H:9]1[CH2:10][CH2:11][CH2:12][CH2:13][C@@H:8]1[N:3]1[CH2:4][CH2:5][CH2:6][CH2:7]1)=[O:20])[CH3:16]

참가 물질

3

반응물 2

HCID 534060122-Ethyl-4-(trifluoromethyl)benzoic acidHCID 66680564cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride2회

생성물 1

HCID 51001073cis-2-Ethyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-4-trifluoromethyl-benzamide

실험 절차

The title compound, white solid, MS: m/e=369.2 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride (intermediate F) and 2-ethyl-4-(trifluoromethyl)-benzoic acid (CAS 854531-63-8).

출처 및 근거

ORD 기록
ord-5c7ccd3e3054465bb1a7609cd2c1abdb
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080541B2

연결된 노트

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