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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 659254생성일: 2026년 10월 26일

2-Cyclopropyl-4-(trifluoromethyl)benzoic acid → cis-2-Cyclopropyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-4-trifluoromethyl-benzamide

https://huagongshe.com/reaction/659254

반응식

참여 물질

역할이름HCID투입량
반응물2-Cyclopropyl-4-(trifluoromethyl)benzoic acidHCID 59438485—
반응물cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochlorideHCID 66680564—
생성물cis-2-Cyclopropyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-4-trifluoromethyl-benzamideHCID 51000992—

반응 단계

The title compound, white solid, MS: m/e=381.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride (intermediate F) and 2-cyclopropyl-4-trifluoromethyl-benzoic acid (intermediate K).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08080541B2
출처 데이터셋uspto-grants-2011_12
ORD IDord-538ca34b2e1b4b4ba88da42ab81e391a
출처 메모uspto-grants-2011_12