2,6-dichloro-4-(trifluoromethyl)benzoic Acid → cis-2,6-Dichloro-N-(2-pyrrolidin-1-yl-cyclopentyl)-4-trifluoromethyl-benzamide
반응식
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:12][C:13]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[C:18]([Cl:26])[C:14]=1[C:15](O)=[O:16]>>[Cl:12][C:13]1[CH:21]=[C:20]([C:22]([F:23])([F:24])[F:25])[CH:19]=[C:18]([Cl:26])[C:14]=1[C:15]([NH:11][C@@H:7]1[CH2:8][CH2:9][CH2:10][C@@H:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:16]참가 물질
3
실험 절차
The title compound, white solid, MS: m/e=395.1 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2,6-dichloro-4-trifluoromethyl-benzoic acid (intermediate Y).
출처 및 근거
- ORD 기록
- ord-88d482be3d9a4252804837fc8a3eedf1
- 출처 데이터셋
- uspto-grants-2011_12