Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Cyclophosphamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Phosphoramidic dichloride, bis(2-chloroethyl)- | HCID 96271 | — |
| 반응물 | Methylamino-1-phenyl-1-propanol | HCID 19933884 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Cyclophosphamide | HCID 2907 | — |
반응 단계
A solution of bis(2-chloroethyl)phosphoramidic dichloride (10 mmol) in ethyl acetate (100 mL) is added dropwise to a solution of commercial 3 methylamino-1-phenyl-1-propanol (10 mmol) and triethylamine (20 mmol) in ethyl acetate (100 mL) at rt. After stirring at rt for 3 days, the salts are filtered off and the combined filtrates are concentrated under vacuum. The crude product is purified by column chromatography on silica.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08080536B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-ba24910390c54d239897abdfb963ae7b |
| 출처 메모 | uspto-grants-2011_12 |