4-Methylpiperazine-1-ethylamine → HCID 57885948, 화합물

HRID 659362

반응식

HRID 659362 반응식
[F:1][C:2]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][NH:8][C:7]2[N:11]=[CH:12][C:13]([C:15]([OH:17])=O)=[CH:14][C:6]1=2.[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][NH2:32])[CH2:26][CH2:25]1>>[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][NH:32][C:15]([C:13]2[CH:12]=[N:11][C:7]3[NH:8][CH2:9][CH2:10][N:5]([CH2:4][C:3]4[CH:18]=[C:19]([F:22])[CH:20]=[CH:21][C:2]=4[F:1])[C:6]=3[CH:14]=2)=[O:17])[CH2:26][CH2:25]1

참가 물질

3

반응물 2

HCID 702844-Methylpiperazine-1-ethylamineHCID 57886060HCID 57886060, 화합물

생성물 1

HCID 57885948HCID 57885948, 화합물수율 82%

실험 절차

1-(2,5-Difluorobenzyl)-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylic acid (40 mg) was reacted with 2(4-methylpiperazin-1-yl)ethylamine as in General Procedure 8 to give the title compound as an orange/brown foam (82% yield). M.p. (foam), LCMS: m/z=431.09 (M+H+), 1H-NMR (CDCl3, 400 MHz) δ 2.28 (s, 3H), 2.41-2.58 (m, 6H), 3.12-3.23 (m, 4H), 3.35-3.39 (m, 2H), 3.42-3.51 (m, 2H), 3.58-3.67 (m, 2H), 4.49 (s, 2H), 5.33 s, 1H), 6.72 (s, 1H), 6.84-6.91 (m, 2H), 6.93-7.04 (m, 1H), 7.10 (s, 1H), 7.85 (d, J=1.5 Hz, 1H).

출처 및 근거

ORD 기록
ord-a1c44e7195514c39bccd170d7eac76ef
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080561B2

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