Sodium Carbonate → 1-[2-(2,3-Dihydro-1,4-benzodioxin-2-yl)ethyl]-4-phenylpiperidin-4-ol

HRID 65954

반응식

HRID 65954 반응식
S(O[CH2:12][CH2:13][CH:14]1[O:19][C:18]2[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=2[O:16][CH2:15]1)(C1C=CC(C)=CC=1)(=O)=O.[OH:24][C:25]1([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)CC(=O)C>[OH:24][C:25]1([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:30][CH2:29][N:28]([CH2:12][CH2:13][CH:14]2[O:19][C:18]3[CH:20]=[CH:21][CH:22]=[CH:23][C:17]=3[O:16][CH2:15]2)[CH2:27][CH2:26]1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 963874-Phenylpiperidin-4-olHCID 128505822-(2-Tosyloxyethyl)-1,4-benzodioxan

생성물 1

HCID 213319841-[2-(2,3-Dihydro-1,4-benzodioxin-2-yl)ethyl]-4-phenylpiperidin-4-ol

시약·촉매·용매 1

HCID 7909Methyl Isobutyl Ketone용매

실험 절차

The mixture of 6.68 g of 2-(2-tosyloxyethyl)-1,4-benzodioxan, 3.54 g of 4-hydroxy-4-phenylpiperidine, 10 g of anhydrous sodium carbonate and 100 ml of 4-methyl-2-pentanone is refluxed 48 hours. It is filtered, evaporated and the residue recrystallized from isopropanol, to yield the 2-[2-(4-hydroxy-4-phenylpiperidino)-ethyl]-1,4-benzodioxan melting at 142°.

후처리

  1. temperatureis refluxed 48 hours
  2. filtrationIt is filtered
  3. customevaporated
  4. customthe residue recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-052c45d224394341b32e4514f5c68f92
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129655

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