Sodium Carbonate → 2-[2-(4-Hydroxy-4-phenylpiperidino)-ethyl]-2,3-dihydrobenzofuran

HRID 65957

반응식

HRID 65957 반응식
S(O[CH2:12][CH2:13][CH:14]1[CH2:18][C:17]2[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=2[O:15]1)(C1C=CC(C)=CC=1)(=O)=O.[OH:23][C:24]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)CC(=O)C>[OH:23][C:24]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:29][CH2:28][N:27]([CH2:12][CH2:13][CH:14]2[CH2:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[O:15]2)[CH2:26][CH2:25]1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 963874-Phenylpiperidin-4-olHCID 544699942-(2-Tosyloxyethyl)-2,3-dihydrobenzofuran

생성물 1

HCID 213319662-[2-(4-Hydroxy-4-phenylpiperidino)-ethyl]-2,3-dihydrobenzofuran

시약·촉매·용매 1

HCID 7909Methyl Isobutyl Ketone용매

실험 절차

The mixture of 4.6 g of 2-(2-tosyloxyethyl)-2,3-dihydrobenzofuran, 2.64 g of 4-hydroxy-4-phenylpiperidine, 10 g of anhydrous sodium carbonate and 100 ml of 4-methyl-2-pentanone is refluxed for 48 hours. It is filtered, evaporated and the residue recrystallized from isopropanol-petroleum ether, to yield the 2-[2-(4-hydroxy-4-phenylpiperidino)-ethyl]-2,3-dihydrobenzofuran melting at 107°.

후처리

  1. temperatureis refluxed for 48 hours
  2. filtrationIt is filtered
  3. customevaporated
  4. customthe residue recrystallized from isopropanol-petroleum ether

출처 및 근거

ORD 기록
ord-90ec3c58a31b4f60a3119a520d15b95a
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129655

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