1,1'-Carbonyldiimidazole → 1-(1,4-Benzodioxan-2-yl-acetyl)-4-ethoxy-4-phenylpiperidine

HRID 65967

반응식

HRID 65967 반응식
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][C:12]([OH:14])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH2:27]([O:29][C:30]1([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1)[CH3:28]>O1CCCC1>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][C:12]([N:33]1[CH2:34][CH2:35][C:30]([O:29][CH2:27][CH3:28])([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:31][CH2:32]1)=[O:14]

참가 물질

5

반응물 3

HCID 682631,1'-CarbonyldiimidazoleHCID 2675342,3-Dihydro-1,4-benzodioxin-2-acetic acidHCID 4173924-Ethoxy-4-phenylpiperidinium chloride

생성물 1

HCID 213319941-(1,4-Benzodioxan-2-yl-acetyl)-4-ethoxy-4-phenylpiperidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

The starting material is prepared as follows: To the solution of 3.3 g of 1,4-benzodioxan-2-yl-acetic acid in 30 ml of tetrahydrofuran, 3.1 g of 1,1'-carbonyldiimidazole are added while stirring followed, after 30 minutes, by 3.5 g of 4-ethoxy-4-phenylpiperidine in 30 ml of tetrahydrofuran. The mixture is stirred for 18 hours at room temperature, evaporated and the residue taken up in ethyl acetate. The solution is washed with water, N hydrochloric acid and saturated aqueous sodium chloride, dried and evaporated, to yield the 1-(1,4-benzodioxan-2-yl-acetyl)-4-ethoxy-4-phenylpiperidine.

후처리

  1. customThe starting material is prepared
  2. stirringThe mixture is stirred for 18 hours at room temperature
  3. customevaporated
  4. washThe solution is washed with water, N hydrochloric acid and saturated aqueous sodium chloride
  5. customdried
  6. customevaporated

출처 및 근거

ORD 기록
ord-0a1564d531ea43d5b0329b72dc458b6d
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129655

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