Ethyl trifluoroacetate → 1-Trifluoroacetyl-4-hydroxy-4-phenylpiperidine

HRID 65969노트

반응식

HRID 65969 반응식
[OH:1][C:2]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[F:14][C:15]([F:22])([F:21])[C:16](OCC)=[O:17]>>[F:14][C:15]([F:22])([F:21])[C:16]([N:5]1[CH2:6][CH2:7][C:2]([OH:1])([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:3][CH2:4]1)=[O:17]

참가 물질

3

반응물 2

HCID 9794Ethyl trifluoroacetateHCID 963874-Phenylpiperidin-4-ol

생성물 1

HCID 14465131-Trifluoroacetyl-4-hydroxy-4-phenylpiperidine

실험 절차

The starting material is prepared as follows: The mixture of 25 g of 4-hydroxy-4-phenylpiperidine and 50 ml of ethyl trifluoroacetate is refluxed overnight and evaporated. The residue is taken up in benzene, the solution washed with 1N hydrochloric acid, dried and evaporated. The residue is recrystallized from ethyl acetate-petroleum ether, to yield the 1-trifluoroacetyl-4-hydroxy-4-phenylpiperidine melting at 123°-125°.

후처리

  1. customThe starting material is prepared
  2. temperatureis refluxed overnight
  3. customevaporated
  4. washthe solution washed with 1N hydrochloric acid
  5. customdried
  6. customevaporated
  7. customThe residue is recrystallized from ethyl acetate-petroleum ether

출처 및 근거

ORD 기록
ord-85b342c49efc47bd97c2025dfa1e28f5
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129655

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