Methylamine → HCID 70625931, 화합물

HRID 65989노트

반응식

HRID 65989 반응식
[Cl:1][C:2]1[C:3]2[C:4](=[N:14][N:15]([CH3:17])[CH:16]=2)[N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH3:18][NH2:19]>>[ClH:1].[CH3:18][NH:19][C:2]1[C:3]2[C:4](=[N:14][N:15]([CH3:17])[CH:16]=2)[N:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[CH3:18][N:14]1[C:4]2=[N:5][C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[CH:7][CH:2]=[C:3]2[CH2:16][N:15]1[CH3:17]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 22756855HCID 22756855, 화합물

생성물 2

HCID 70625931HCID 70625931, 화합물HCID 131710884HCID 131710884, 화합물

실험 절차

17 g. of 4-chloro-2-methyl-6-phenyl-2H-pyrazolo [3,4-b]pyridine (0.07 mol.) and 60 ml. of alcoholic methylamine (270 g/l) are heated at 150°-160° in an autoclave for four hours. After cooling to room temperature, the solution is evaporated in vacuo and the residue is extracted with chloroform. To the chloroform extract is added ethereal hydrochloric acid to give the crude hydrochloride of N,2-dimethyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine which, after treatment with ether, becomes crystalline.

후처리

  1. customthe solution is evaporated in vacuo
  2. extractionthe residue is extracted with chloroform
  3. extractionTo the chloroform extract
  4. additionis added ethereal hydrochloric acid

출처 및 근거

ORD 기록
ord-bcf835d3b3d24125adbc8e58bae80fc5
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129738

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