Venlafaxine Hydrochloride → Venlafaxine

HRID 659915

반응식

HRID 659915 반응식
[CH3:1][N:2]([CH2:4][CH:5]([C:14]1([OH:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:6]1[CH:7]=[CH:8][C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:3].Cl>C(O)C>[CH3:1][N:2]([CH2:4][CH:5]([C:14]1([OH:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:6]1[CH:7]=[CH:8][C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:3]

참가 물질

3

반응물 1

HCID 62923Venlafaxine Hydrochloride

생성물 1

HCID 5656Venlafaxine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A composition comprising a drug of the structural formula was prepared as follows: first, a drug composition was prepared by passing 840 grams of venlafaxine hydrochloride, 100 grams of hydroxypropylcellulose having a molecular weight of approximately 60,000 grams per mole, and 50 grams of polyvinylpyrrolidone having a molecular weight of approximately 40,000 grams per mole, were passed through a sizing having openings of approximately 420 microns, and mixed in a planetary mixer to yield a uniform blend. Then, anhydrous ethyl alcohol was added to the mixture with stirring to produce a cohesive damp mass. The resulting damp mass was sized through a sieve having an opening of 840 microns, producing coated venlafaxine drug, which was air dried overnight. The resulting dried coated venlafaxine drug was passed again through the sizing screen having an 840 micron opening. Next, 10 grams of magnesium stearate, sized to 180 microns, was tumble mixed into the blend.

후처리

  1. customwas prepared
  2. customfirst, a drug composition was prepared
  3. additionmixed in a planetary mixer
  4. customto yield a uniform blend
  5. customto produce a cohesive damp mass

출처 및 근거

ORD 기록
ord-29338831090b4417b621fb9e311e7d13
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084059B2

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