Ammonia → HCID 13359100, 화합물

HRID 65994

반응식

HRID 65994 반응식
[NH2:1][C:2]1[CH:3]=[CH:4][N:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.C([O:15][C:16](=O)[CH2:17][C:18](=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)C.N>O>[C:7]1([N:5]2[N:6]3[C:16](=[O:15])[CH:17]=[C:18]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[N:1]=[C:2]3[CH:3]=[CH:4]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 7170Ethyl benzoylacetateHCID 5943201-phenyl-1H-pyrazol-3-amine

생성물 1

HCID 13359100HCID 13359100, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 10 g. of 5-amino-2-phenylpyrazole (0.063 mol.),12.1 g. of benzoylacetic acid ethyl ester (0.063 mol.) and 50 g. of polyphosphoric acid is heated at 110°-120° with stirring for 90 minutes. After cooling, 200 ml. of water and then concentrated aqueous ammonia is added under external cooling to adjust the mixture to pH 9. The collected 1,5-diphenylpyrazolo[1,5-a]pyrimidin-7(1H)-one is washed with water and dried at 70°, yield: 17 g. (94%); m.p. 194°-200°. A sample, recrystallized from absolute ethanol, melts at 205°-207°.

후처리

  1. additionA mixture of 10 g
  2. temperatureAfter cooling
  3. temperatureunder external cooling
  4. washThe collected 1,5-diphenylpyrazolo[1,5-a]pyrimidin-7(1H)-one is washed with water
  5. customdried at 70°
  6. customA sample, recrystallized from absolute ethanol, melts at 205°-207°

출처 및 근거

ORD 기록
ord-c89aecfb2a7e473eb71eb9b49edc3698
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129738

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